In that work, researchers used nuclear magnetic resonance (NMR) spectroscopy and complex computer simulations to examine the fundamentals of how different molecules interact with various surfaces and ligands, including how and where binding happens, and if certain molecular interactions affect the binding process. This new paper builds upon research by the Cramer Lab recently published in Biotechnology and Bioengineering. 'Our group is trying to ramp up the intellectual level of this kind of analysis in a variety of ways.'

'This is part of a very big effort to understand the fundamentals of how these molecules interact with surfaces,' said Cramer, a member of the Rensselaer Center for Biotechnology and Interdisciplinary Studies (CBIS), where the work was performed. Ions or molecules, known as ligands, are developed to bind to specific components that should either be saved or discarded during this process. In research published in Langmuir, a team led by Steven Cramer, an endowed chair professor of chemical and biological engineering at Rensselaer Polytechnic Institute, explored the fundamentals of how different molecules interact with various surfaces during the purification process.Ĭramer is a leading expert in chromatographic bioprocessing, a separation technique used in biopharmaceutical purification to selectively choose which components of a protein mixture should be kept and which components should be removed.

Purify app ios